.. I recommend following this skill tree path which was explicitly designed to make the gaming experience as pleasant as possible for new players. That being said, it focuses more on survivability and comfort than damage since these are way more important at the beginning, but the guide will elaborate on options to adjust the skill tree in order to be more damage centric for the endgame later.
Pantheons are strong permanent passive effects your character gets by defeating specific bosses. You can have a major and a minor Pantheon. Here, you can choose your major Pantheon ‘Soul of the Brine King‘ after killing the final boss of Act 6 by talking to Sin who provides you the following buff: “You cannot be Stunned if you’ve been Stunned or Blocked a Stunning Hit in the past 2 seconds”. This Pantheon is also your major endgame Pantheon which means you won’t change it anymore.
Did you know? You can switch Pantheons on-the-fly whenever you want to without having any opportunity costs. In order to do so, just talk to so Sin in town. Additionally, Pantheons can be upgraded to be more powerful later in the game.